This article explores Motivational Interviewing (MI) as an evidence-based, patient-centred approach that transforms traditional, prescriptive consultations into collaborative conversations. It outlines MI’s core techniques—such as open-ended questioning, reflective listening, and eliciting change talk—and demonstrates how these methods effectively address patient ambivalence to foster meaningful behavioural changes across conditions like diabetes, hypertension, smoking cessation, and obesity. The inclusion of detailed clinical examples and case studies highlights MI’s practical application in both general practice and specialist settings, underscoring its significant impact on treatment adherence, clinical outcomes, and the overall therapeutic alliance.